Together this results in an erection. c GMP is normally broken down by another chemical in the body phosphodiesterase type 5. Viagra prevents its action, hence stopping the breakdown of c GMP. This means that the blood vessels are dilated for longer, resulting in improved blood flow to the penis and helping it to maintain an erection.
All PDE5 inhibitors Viagra, Cialis and Levitra should be used with caution by men with a physical abnormality of the penis, such as severe curvature, scarring or Peyronie's disease. Patients with Peyronie's disease should always consult with their doctor or urologist before using any erectile medications.
Are you tired of your doctor visits? Well, 90 percent of people do. When you order drugs from our online pharmacy as online generic Viagra or Cialis online you will get it without prescription. We also offer unique shipping terms. Buy Viagra online with overnight shipping today and get it tomorrow. In his book Understanding Peyronie’s Disease Dr. Laurence Levine says “The key point to remember is that if you have Peyronie’s Disease and you use Viagra or another oral erection drug to enhance your erections, it is possible that you could reinjure your penis during sex.
It is therefore wise to be careful about your sexual activity in order to reduce the likelihood of recurrent trauma and reactivations of the Peyronie’s process” Understanding Peyronie’s Disease, page 44 It does not explain why but it is fair to assume there is a risk of aggravating the Peyronie's condition, which leads us to the next more sensitive question... G. Hellstrom found that number of patients with Peyronie's had increased since the advent of Viagra International Journal of Impotence Research 2002 14, pages 353-360. There is no sustainable evidence that using Viagra can cause Peyronie's disease but there are some reasons for concern. J. They considered this to be either because more men are becoming manifest and / or not hesitant anymore to come to clinics for such evaluations. Dr. Drogo Montague, the director of the center for genitourinary reconstruction at the Cleveland Clinic in Ohio, sees it differently. Study from 2002 into the 'Role of oxidative stress and antioxidants in Peyronie's disease' by S. C. Sikka and W. "Erectile dysfunction medications such as Viagra might protect some men -- and harm others. These medications are made in India, and the manufacturer is licensed by the state, the companies are Indian FDA approved. Every package we send out will include a copy of the Certificate of Analysis that we get from the laboratory of the manufacturer, and in full compliance of Indian law.
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Buy cheap Cialis and cheap Viagra online from the comfort of your home or office. How does Viagra work? The simple explanation is that Viagra relaxes muscles and increases blood flow to particular areas in the body. The more detailed explanation is that Viagra works by maintaining the level of c GMP cyclic guanosine monophosphate in the smooth muscle cells. When men get sexually stimulated, the nervous system releases nitric oxide NO that stimulates enzyme that produces c GMP that relaxes the smooth muscle cells.
This causes the arteries in the penis to dilate, allowing the blood to flow more easily into the penis. It also causes the erectile tissue itself to fill with blood.
You may want to investigate other options to improve your erection quality, like using Penis Vacuum Pump. If you are fortunate enough not to have Peyronie's disease, then take good care of your penis and avoid putting extra strain on it whether you use Viagra or not.
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In men with mild erection problems, the drugs can bring a medium-soft erection up to full strength, "so there's less chance of injury during normal sexual activity," Montague says. But for men with severe erectile dysfunction, the drugs might make matters worse, by providing an erection that's just about firm enough for penetration but still soft enough to buckle easily during intercourse" Los Angeles Times, February 09, 2009 And we know that penis buckling can result in men developing Peyronie's disease. This German study from 2002 seems to confirm these suspicions "Along these lines, most clinicians note that the number of Peyronie's patients has increased since the advent of oral sildenafil. With more men being successfully treated for erectile dysfunction ED, an increasing number of Peyronie's cases are becoming manifest and being presented for evaluation" International Journal of Impotence Research, October 2002 Interesting research Histopathological effects of sildenafil citrate on rat corpus cavernosum from 2004 used mice to look at the long term effects of Viagra on the penis and its components. The original article was published in Acta Histochemica Volume 106, Issue 1, 26 February 2004, Pages 37–45.
This research showed that prolonged use of Sildenafil results in fibrotic changes of the corpus cavernosum in both male and female rats. Cure Peyronie's goes through this research in detail and concludes there is "strong evidence that the prolonged use of sildenafil citrate is related to penile injury and aberrant healing, leading to an increased incidence of PD". Still, more studies are required in this area. It is though unlikely to be welcome by the big pharmaceutical giants that are making astonishing amount of money from the sale of PDE5 inhibitors worldwide.